Article-Journal

Frailty in adults with CKD and validation of the kidney failure risk equation in frailty subgroups

Key Points: The four-variable kidney failure risk equation (KFRE) does not accurately estimate kidney failure risk in frail individuals. Prognostication of kidney failure is …

heather-walker

Frailty in adults with CKD and validation of the kidney failure risk equation in frailty subgroups

Key Points: The four-variable kidney failure risk equation (KFRE) does not accurately estimate kidney failure risk in frail individuals. Prognostication of kidney failure is …

heather-walker

A case study in statistical software development for advanced evidence synthesis: the combined value of analysts and research software engineers

Background: Since 2015, the Complex Reviews Synthesis Unit (CRSU) has developed a suite of web-based applications (apps) that conduct complex evidence synthesis meta-analyses …

naomi-bradbury

Network meta-analysis: the way forward for evidence-based decisions

Systematic reviews and meta-analyses play a crucial role in clinical research by providing a means of evaluating the effectiveness of interventions in situations of uncertainty. …

nishant-jaiswal
Joint modelling of longitudinal processes and time-to-event outcomes in heart failure: systematic review and exemplar examining the relationship between serum digoxin levels and mortality featured image

Joint modelling of longitudinal processes and time-to-event outcomes in heart failure: systematic review and exemplar examining the relationship between serum digoxin levels and mortality

Background: Joint modelling combines two or more statistical models to reduce bias and increase efficiency. As the use of joint modelling increases it is important to understand …

ryan-j.-field

FAIR Data Pipeline: provenance-driven data management for traceable scientific workflows

Modern epidemiological analyses to understand and combat the spread of disease depend critically on access to, and use of, data. Rapidly evolving data, such as data streams …

sonia-natalie-mitchell

Following the Science? Comparison of methodological and reporting quality of covid-19 and other research from the first wave of the pandemic

Background: Following the initial identification of the 2019 coronavirus disease (covid-19), the subsequent months saw substantial increases in published biomedical research. …

terence-j.-quinn

Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study

Background: Alcohol consumption is a leading contributor to death and disability worldwide, but previous research has not examined the effects of different patterns of alcohol …

bhautesh-dinesh-jani